Anthelmintic activity of dandielion (Taraxacum officinale Wigg.)
Pages: 57-61.
Gorchakov V.V., PhD in Biology, leading researcher,
Vorotnikov V.P., PhD in Biology, associated researcher
Scientific and Research Veterinary Institute of the Non-Chernozem Zone of the Russian Federation, Nizhny Novgorod, Russia
E-mail: nivinzrf@mail.ru
Epizootological situation in the Nonblack Soil Zone shows a trend towards an annual increase in fasciolosis prevalence – anthropo-zoohelminthosis of humans and animals. Potential risk increases of further deterioration of the situation concerning the geographical distribution of Fasciola hepatica which actively occupying new agricultural areas. One of the key elements in the complex of anti-fasciolosis measures is a pasture prophylaxis with use of environmentally friendly herbal remedies. Conducting larval deworming gives the greatest therapeutic and prophylactic effect as not only prevents the spread of invasion but also disease in animals. The aim of the present study was to reveal the trematocidal activity of the dandelion (Taraxacum officinale Wigg.) against larvae of the liver fluke (Fasciola hepatica) which locate in digestive tract of definitive host before invasion. Researches were conducted in the laboratory of the FGBNU “NIVI NZ Russia” and on base farms of subzones of southern taiga and mixed forests of the Nizhny Novgorod region. Expressed trematocidal activity of the dandelion with intense effectiveness of 55.88% was revealed experimentally on the laboratory model (grey rabbits). It was estimated that remedies prepared from the herb of the dandelion belong to low toxic substances and do not cause collateral effects on non-target objects in particular on grazing farm animals and do not possess cumulative properties (Kn ≥ 2.5). Because of good palatability the dandelion can be used in herbages as a valuable forage plant improving digestion, increasing appetite and enhancing lactation. At the same time the dandelion is an effective therapeutic feed additive with trematocidal effects with intense effectiveness of 55.88% on small bulls of black-motley breed.
Keywords: Fasciola hepatica, larvae, prophylaxis, plants, anthelmintics
References
1. Gorchakov V.V., Skira V.N., Kim R.E. Krysy – definitivnye khozyaeva F. hepatica na pastbishchakh. [Rats – definitive hosts of F. hepatica on pastures]. Nauchnye osnovy profilaktiki i lecheniya, infektsionnykh, invazionnykh i nezaraznykh bolezney s.-kh. zhivotnykh. [Scientific basis of prevention and treatment of infectious, invasive and noncontagious diseases of agricultural animals]. N. Novgorod, 2004. pp. 116-120.
2. Dreyfuss G., Vignoles P., Rondelaud D. Fasciola hepatica: the infectivity of cattleorigin miracidia had increased over the past years in central France. Parasitol Res. 2007. V. 101. no. 4. pp. 1157-1160.
3. Silvestre A., Leignel V., Berrag B., Gasnier N., i dr. Sheep and goat nematode resistance to anthelmintics: pro and cons among breeding management factors. Veter. Res. 2002. V. 33. no. 5. pp. 465-480.
4. Gulyaev A.S., Semenova S.K., Arkhipov I.A. Problema ustoychivosti Fasciola hepatica k benzimidazolam: opyt mirovoy nauki. [The problem of Fasciola hepatica resistance to benzimidosoles: experience of world science]. Rossiyskiy parazitologicheskiy zhurnal. 2012. no. 1. pp. 104-108.
5. Spravochnik po veterinarnoy gel'mintologii. [Handbook of veterinary gelmintology]. Pod red. V.S. Ershova. Moscow: Kolos, 1964. p. 17.
6. Kuticic V. Unapredenje mitodike nalazenja vitalnih metacerkarija Fasciola hepatica u travnom otkosu. Acta parasitol Jugosl. 1977. V. 8. no. 2. pp. 115-131.
7. Arkhipov I.A. Standartizatsiya metodov ispytaniy i otsenka effektivnosti antgel'mintikov. [Standardization of test methods and evaluation of effectiveness of anthelmintics]. Veterinariya. 2004. no. 5. pp. 31-35.
8. Rukovodstvo po eksperimental'nomu (doklinicheskomu) izucheniyu novykh farmakologicheskikh veshchestv. [Manual on experimental (preclinical) study of new pharmacological substances]. Pod obshch. Red. R.U. Khabrieva. 2-e izd., pererab. i dop. Moscow: Meditsina, 2005. 832 p.
9. Lim R.R., Rink K.J., Hass H.J., Soage-Echague E. A method for the walecation of cumulation and subchronic median effective. Arch. Int. Phar-macodyn. 1961. V. 130. P. 335-353.
10. Kondrashkina M.I., Samsonova V.P. Oduvanchik lekarstvennyy kak indikator zabroshennykh pakhotnykh zemel'. [Taraxacum officinale as an indicator of abandoned arable land]. Problemy agrokhimii i ekologii. 2010. no. 1. pp. 24-27.
11. Golovkin B.N., Rudenskaya R.N., Trofimova I.A., Shreter A.I. Biologicheski aktivnye veshchestva rastitel'nogo proiskhozhdeniya. [Biological active substances of plant origin]. Moscow: Nauka, 2001. 350 p.
12. Vasilevich E.N. Deystvie atsemidofena na ektsistirovannykh adoleskariev Fasciola hepatica pri eksperimental'nom fastsioleze. [The effect of azetidine on ecsistered adolescaria Fasciola hepatica in the experimental fasciolata]. Byul. Vses. in-ta gel'mintologii, 1983. Iss. 35. p. 51.
13. Morrison R., Boyd R. Organicheskaya khimiya. [Organic chemistry]. Moscow: Mir, 1974. 1132 p.
14. Sredstvo dlya obezdvizhivaniya miratsidiev trematod. [The means for immobilization in the miracidium trematode]. Gorchakov V.V. / A.S. SSSR. no. 586654. 2 p.
15. Maev I.V., Kazyulin A.N., Kucheryavyy Yu. A. Profilakticheskoe i klinicheskoe znachenie vitaminov. [Preventive and clinical importance of vitamins]. Farmatsevticheskiy vestnik. 2002. no. 12. pp. 17-19.
16. Athanasiadou S., Kyriazakis I., Jackson F., Coop R.L. Direct anthelmintic effects of condensed tannic towards different gastrointestinal nematodes of sheep: in vitro and in vivo studies. Vet. Parasitol. 2001. V. 99 (3). P. 205-219.
17. Orlov B.N., Gelashvili D.B., Ibragimov A.K. Yadovitye zhivotnye i rasteniya SSSR. [Poisonous animals and plants of the USSR]. Moscow: Vyssh. shk., 1990. 272 p.
18. Rastitel'noe trematotsidnoe sredstvo protiv ektsistirovannykh lichinok Fasciola hepatica. [Trimeta-zidine herbal remedy against ecsistered larvae of Fasciola hepatica]. Patent RF no. 2508119. 2014.
