Estimating the degree of body immunodepression in leukosis-infected cattle
Pages: 53-57.
Smirnov Yu.P., DSc in Veterinary Medicine, leading researcher,
Suvorova I.L., chief biochemist
Research Veterinary Institute of Non-Chernozem Zone of the Russian Federation, Nizhny Novgorod, Russia
E-mail: nivinzrf@mail.ru
The paper presents some results of surveys estimating of body immunodepression in leukosis-infected cattle depending on the total percentage of juvenile, stab and segmentated neutrophilic leukocytes in peripheral blood that are the first how protect body against infectious diseases and foreign invaders. If the value is 0 to 20%, immunodepression is estimated at high number of diseased and suspect animals – about 90.7% during 12 months. At total content of these cells about 21 to 30% - as lowered with 31.8% of diseased and suspect animals; at 31% and more – as low with 0.0…2.5% of diseased and suspect animals. Dependency was revealed makes it possible to modulate the degree of sensitivity to the immunosuppressive effects of the BLV in susceptible animals. It is believed that various changes in the content of the neutrophils are evident in all malignant re-birth of marrowy and lymphoid tissues. Estimating the degree of body immunodepression in leukosis-infected cattle in asymptomatic stage of leukosis depending on the total percentage of neutrophilic leukocytes, identification of animals with the high degree of body immunodepression and their timely segregation will prevent the possible death and improve the effectiveness of control and eradication programs for BLV infection. In addition, it is possible to get meat products from these animals fit for food of man.
Keywords: bovine leukosis virus (BLV), immunodepression, juvenile, stab and segmentated neutrophilic leukocytes
References
1. Gorodilova V.V., Boeva M.N. Immunobiologiya opukholevogo rosta. [Immunobiology of tumor growth]. Moscow: Med., 1983. 240 p.
2. Kudryavtsev A.A, Kudryavtseva L.A. Klinicheskaya gematologiya zhivotnykh. [Clinical hematology of animals]. Moscow: Kolos, 1974. 309 p.
3. Chaklin A.V., Vikhert A.M i dr. Zlokachestvennye opukholi. [Malignant tumors]. V kn.: Epidemiologiya neinfektsionnogo zabolevaniya. [Epidemiology of non-infectious disease]. Moscow: Med., 1990. pp. 142-145.
4. Gritsman Yu. Posleslovie. Rak: eksperimenty i gipotezy. [Afterword. Cancer: experiments and hypothesizes]. Moscow: Mir, 1977. pp. 338-352.
5. Metodicheskie rekomendatsii po ozdorovleniyu plemennykh khozyaystv ot leykoza krupnogo rogatogo skota. [Methodical recommendations on improvement of breeding farms from leukemia]. Moscow: VIEV, 2009.
6. Shishkov V.P. Opukholi i leykozy zhivotnykh (biologicheskie, ekonomicheskie i veterinarno-meditsinskie aspekty). [Tumors and leukosis in animals (biological, economic-and-veterinary and medical aspects)]. Problemy eksperimental'noy onkologii i leykozov cheloveka i zhivotnykh. [Problems of experimental oncology and leukosis in man and animals]. Moscow: Kolos, 1979. pp. 11-22.
7. Lebedev K.A., Ponyakina I.D. Immunogramma v klinicheskoy praktike. [Immunogram in clinical practice]. Moscow: Nauka, 1990. 224 p.
8. Vlasenko V., Ivanov A., Dudoladova T. Metabolicheskaya aktivnost' neytrofilov periferi-cheskoy krovi pri leykoze krupnogo rogatogo skota. [Metabolic activity of neutrophils of peripheric blood at bovine leukosis]. Veterinariya sel'skokhozyaystvennykh zhivotnykh. 2014. no. 12. pp. 27-31.
9. Rozenberger G. Voprosy diagnostiki, etiologii i bor'by s leykozom krupnogo rogatogo skota. [On diagnosis, etiology and treatment of bovine leukosis]. Problemy eksperimental'noy onkologii i leykozov cheloveka i zhivotnykh. [Problems of experimental oncology and leukosis in man and animals]. Moscow: Kolos, 1979. pp. 202-305.
10. Khokhlova M.P., Osechinskiy I.V. Epidemiologicheskie podkhody k izucheniyu virusnoy gipotezy leykozov cheloveka. [Epidemiological approaches to the study of viral hypothesis of man leukemia]. Problemy eksperimental'noy onkologii i leykozov cheloveka i zhivotnykh. [Problems of experimental oncology and leukosis in man and animals]. Moscow: Kolos, 1979. pp. 223-229.
